2026-09-19T19:14:28Zhttps://wakespace.lib.wfu.edu/server/oai/requestoai:null:10339/304042026-09-02T13:10:23Zcom_10339_14934col_10339_38132
Davis, Nicole
2011-02-16T21:42:20Z
2011-08-02T08:30:10Z
2010
https://wakespace.lib.wfu.edu/handle/10339/30404
The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response through production of ROS. Deficiencies in components of the phagocytic NADPH oxidase lead to weakened host defense, as seen in chronic granulomatous disease. There are also non-phagocytic homologues of the phagocytic NADPH oxidase (NOX) found in a broad range of tissues. These homologues play roles in host defense, signaling, regulation of cell growth and metabolism. Aberrant NOX function has been implicated in several disease states such as certain cancers and Alzheimer's disease. Increased expression and dysregulation of the non-phagocytic NADPH oxidase has been indicated to have a role in abnormal growth in cancers.
en
Wake Forest University
Lipid Binding
NADPH Oxidase
NMR
NOXO1
PX Domain
SPR
Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain
Dissertation
Horita, David A
Reid, Sean
Hollis, Thomas
Kucera, Greg
McPhail, Linda C
Biochemistry and Molecular Biology
2011-08-02
open.access