2026-09-21T23:43:20Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/304062026-09-02T16:49:44Zcom_10339_14934col_10339_38132

Tan, Huan 2011-02-16T21:42:23Z 2011-02-16T21:42:23Z 2010 https://wakespace.lib.wfu.edu/handle/10339/30406 Tissue function depends heavily on perfusion, a process which brings the blood supply to the tissue through the arterial system and removes the metabolic by-products via the veins. Abnormalities and disruptions in this process can have profound effects. Cerebral blood flow (CBF), a quantitative perfusion measurement in the brain in units of milliliters of blood per 100 grams of tissue per minute, can be used to understand complex neurophysiology and reveal neuropathology. Cerebral perfusion is conventionally measured with the use of an exogenous contrast agent that is invasive and has limited repeatability. A new class of technique, known as arterial spin labeling (ASL), uses the water molecules in the arterial blood as an endogenous tracer to measure CBF via magnetic resonance imaging. ASL is therefore completely non-invasive and has been widely adapted in both clinical and research environments. en Wake Forest University Arterial Spin Labeling Cerebral Blood Flow Image Acquisition Magnetic Resonance Imaging Improving the Robustness of Perfusion Imaging with Arterial Spin Labeling Magnetic Resonance Imaging Dissertation Kraft, Robert A Daunais, James B Hamilton, Craig A Hoge, W. Scott Plemmons, Robert J Biomedical Engineering open.access