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oai:null:10339/304172026-09-02T10:53:41Zcom_10339_14934col_10339_38132

Love, Cheraton Fabrice 2011-02-16T21:42:30Z 2011-02-16T21:42:30Z 2010 https://wakespace.lib.wfu.edu/handle/10339/30417 Bacteria face many challenges during infection of the host. Initiation of infection requires attachment to host surfaces. <italic>Bordetella</italic> species possess several virulence factors that mediate binding to the host such as filamentous hemagglutinin and pertactin. A crucial component of successful colonization is evasion of host defenses. Biofilms have been proposed to promote bacterial persistence by suppressing the effectiveness of host responses. A hallmark of mature biofilms is the production of a matrix composed of extracellular polymers including proteins, DNA and polysaccharides. We have shown that the <italic>bps</italic> locus is required for biofilm formation and production of the <italic>Bordetella</italic> polysaccharide (Bps), a major constituent of <italic>Bordetella</italic> biofilms. en Wake Forest University antimicrobial peptides biofilms Bordetella The Role of Bps Polysaccharide in Bordetella Resistance to Host Innate Defenses Dissertation Deora, Rajendar McPhail, Linda Parks, Griffith Alexander-Miller, Martha Kock, Nancy Microbiology & Immunology open.access