2026-09-21T14:29:57Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/304322026-09-18T11:48:08Zcom_10339_14934col_10339_38132

Jia, Lin 2011-02-16T21:42:40Z 2012-11-24T09:30:07Z 2010 https://wakespace.lib.wfu.edu/handle/10339/30432 Niemann-Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein critical for intestinal absorption of dietary and biliary cholesterol. Ezetimibe, by inhibiting NPC1L1 function, is widely used to lower blood cholesterol in humans. Recently, NPC1L1 deficiency or ezetimibe treatment has been shown to improve hepatic steatosis in rodents and humans without a defined mechanism. In the first project, we found that genetic inactivation of NPC1L1 in mice prevents high fat diet (HFD)-induced fatty liver by inhibiting hepatic de novo lipogenesis, at least in part, through protecting mice against HFD-induced insulin resistance and hyperinsulinemia, a state known to drive hepatic lipogenesis. . en Wake Forest University Cholesterol Hepatic Steatosis NPC1L1 Obesity THE ROLE OF NIEMANN-PICK C1-LIKE 1 (NPC1L1) PROTEIN IN CHOLESTEROL TRANSPORT AND METABOLIC DISEASES Dissertation Yu, Liqing Rudel, Lawrence L Parks, John S Shelness, Gregory S Shi, Hang Molecular Pathology 2012-11-24 open.access