2026-09-18T20:14:25Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/304352026-04-21T20:58:57Zcom_10339_14934col_10339_38132

Weimer, Kristin 2011-02-16T21:42:43Z 2011-02-16T21:42:43Z 2010 https://wakespace.lib.wfu.edu/handle/10339/30435 Otitis media is a major public health problem in pediatrics worldwide. It is the number one reason for pediatric office visits, new antibiotic prescriptions and surgery in children. The two most commonly isolated pathogens from otitis media infection are <italic>Haemophilus influenzae</italic> and <italic>Streptococcus pneumoniae</italic>. Once established, these bacteria can cause persistent and/or recurrent infections and are often refractory to antibiotic therapy. One hypothesis to explain this persistence is the presence of biofilm communities, which are inherently resistent to host clearance mechanisms and antibiotics. Biofilm formation by otopathogens has been demonstrated in vitro, in a chinchilla model of experimental otitis media and on human patient samples. en Wake Forest University beta lactam biofilm coinfection Haemophilus influenzae otitis media Streptococcus pneumoniae The Effect of Haemophilus influenzae and Streptococcus pneumoniae coinfection on Otitis Media Disease Progression and Treatment Efficacy Dissertation Swords, W. Edward High, Kevin P McCall, Charles E Grayson, Jason M Microbiology & Immunology open.access