2026-09-20T16:07:53Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/334172026-09-02T12:24:14Zcom_10339_14934col_10339_38132

Pryor, Edward E. 2011-07-14T20:34:52Z 2012-07-14T08:30:17Z 2006 https://wakespace.lib.wfu.edu/handle/10339/33417 The Protein Structure Initiative, a project on the scale of the Human Genome Project aimed at protein structure determination, has successfully identified the structure of multiple human proteins. Unfortunately, knowledge of structure alone provides little insight into a protein's function within the body. A protein's function is defined by its active site, the area of the protein structure involved in the chemistry of its function. Because a protein's structure is related to its sequence, there currently exist many methods which compare protein sequences in an attempt to extrapolate function. Although effective for specific cases, there exist many documented instances where two proteins have similar structure and function, but dissimilar sequences. This occurs because structure determines the functionality of the protein, not the sequence. en Wake Forest University Parallel Programming Protein Active Sites Protein Data Bank Relational Database PASSS: Protein Active Site Structure Search Thesis Fetrow, Jacquelyn S. John, David J. Salsbury, Jr., Freddie R. Turkett, Jr., William H. Computer Science 2012-07-14 open.access