2026-09-21T04:14:04Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/334192026-09-02T12:24:12Zcom_10339_14934col_10339_38132

SARMA, SAURAV JYOTI 2011-07-14T20:34:54Z 2012-07-14T08:30:17Z 2011 https://wakespace.lib.wfu.edu/handle/10339/33419 This project delves into the mechanistic details of the photochemical reactions of alkoxy-anthraquinones in various media in order to devise potential applications of these photoreactions. Currently, Photodynamic therapy relies on the generation of singlet oxygen in cells which is not efficient under hypoxic conditions such as that in cancer cells. Development and optimization of a water soluble caged anthraquinone that can release a biocidic aldehyde, 4-HNE, upon photolysis, has been studied as a possible alternative to overcome this limitation of photodynamic therapy at present. The impact of variations in substitution, conditions and additives on the course of the mechanistic pathways involved in the process, are investigated. en Wake Forest University caged-anthraquinone hydrogen abstraction Norrish reaction photo-Claisen radical cyclization single electron transfer SYNTHETIC AND MECHANISTIC PHOTOCHEMISTRY OF ALKOXY ANTHRAQUINONES: POTENTIAL UTILITY IN DRUG DELIVERY AND SYNTHETIC METHODOLOGIES Dissertation JONES, PAUL B CONNER, WILLIAM E BIERBACH, ULRICH COLYER, CHRISTA L KING, STHEPHEN B Chemistry 2012-07-14 open.access