2026-09-23T06:38:13Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/334292026-09-18T11:58:07Zcom_10339_14934col_10339_38132

Pandya, Hetal Vinod 2011-07-14T20:35:08Z 2012-01-14T09:30:11Z 2011 https://wakespace.lib.wfu.edu/handle/10339/33429 Glioblastoma multiforme (GBM) is a primary brain tumor of dismal prognosis. Patients with GBM have a median survival rate of 14.5 months inspite of multimodality treatment involving surgery, radio- and chemotherapy. This warrants an intensive search for efficient new therapies. Interleukin 13 receptor alpha 2 (IL-13Rα2) is an internalized, plasma membrane receptor for IL-13. IL-13Rα2 is over-expressed in around 75 percent of GBM patients. One of our goals is to develop specific therapeutic delivery vehicles and imaging agents targeting IL-13Rα2. en Wake Forest University blood-brain tumor barrier double-specificity intracellular trafficking phage display library sub-cellular compartment delivery tumor-associated antigen SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME Dissertation Debinski, Waldemar Dubey, Purnima Hantgan, Roy Kridel, Steven Lively, Mark Molecular Genetics & Genomics 2012-01-14 open.access