2026-09-18T19:27:32Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/334592026-09-02T14:36:44Zcom_10339_14934col_10339_38132

Brown, Amanda Lynn 2011-07-14T20:35:38Z 2012-07-14T08:30:17Z 2011 https://wakespace.lib.wfu.edu/handle/10339/33459 Dietary omega-3 polyunsaturated fatty acids, primarily eicosapentaenoate (EPA) and docosahexaenoate (DHA), attenuate chronic diseases such as atherosclerosis. However, fatty fish, the richest dietary source of omega-3 fatty acids, is consumed in low quantities in the U.S. Therefore, we sought to determine whether a botanical oil, echium oil from Echium plantagineum that is enriched in stearidonic acid (SDA; 18:4 n-3), will alter monocyte and macrophage phenotypes in murine models of atherosclerosis. This dissertation addresses the considerable gaps in knowledge regarding the atheroprotective and anti-inflammatory potential of echium oil supplementation. Furthermore, this work helped elucidate the role of omega-3 fatty acids in CVD prevention, and clarify the immunomodulatory properties of omega-3 fatty acids. en Wake Forest University alternative echium oil fish oil inflammation Ly6C SDA THE ROLE OF OMEGA-3 FATTY ACIDS IN DETERMINING MONOCYTE AND MACROPHAGE PHENOTYPES IN EXPERIMENTAL ATHEROSCLEROSIS Dissertation Parks, John S. Dawson, Paul A. Alexander-Miller, Martha Seeds, Michael C. Mishra, Nilamadhab Yoza, Barbara A. Molecular Medicine and Translational Science 2012-07-14 open.access