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Beauchamp, Nicole 2011-07-14T20:36:31Z 2012-07-14T08:30:19Z 2011 https://wakespace.lib.wfu.edu/handle/10339/33501 Unlike many other tissues, the lung is constantly assaulted with foreign antigens, both environmental and infectious. This includes a large number of viruses which spread via aerosolized droplets. In order for the body to mount an adaptive immune response to a pathogen, T cells circulating through lymph nodes (LN) must be alerted to the presence of infection in the periphery. This occurs as a result of presentation of pathogen derived epitopes on professional antigen presenting cells (APC), primarily dendritic cells (DC). While an important role for dendritic cells (DC) as the activators of naive T cells is clear, the contribution of distinct DC subsets in this process is less understood. Multiple DC subsets are present within the lung tissue (CD103+ DC and CD11b+ DC) and draining lymph nodes (MLN) (CD8α+), and as such, all are potential regulators of T cell activation (for review see1,2). These studies sought to understand how DC subsets contribute to the generation of virus-specific CD8+ T cells following pulmonary viral infection. en Wake Forest University CD8 T cells dendritic cells lung mouse respiratory infection vaccinia virus Understanding the Role of Dendritic Cell Subsets in the Generation of a CD8+ T Cell Response Following Pulmonary Vaccinia Viral Infection Dissertation Alexander-Miller, Martha A Grayson, Jason Parks, Griffith High, Kevin Hiltbold-Schwartz, Elizabeth Barton, Erik Molecular Medicine and Translational Science 2012-07-14 open.access