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oai:null:10339/361442026-09-18T13:41:26Zcom_10339_14934col_10339_38132

Nguyen, Tam Minh 2011-09-08T08:35:47Z 2012-09-08T08:30:06Z 2011 https://wakespace.lib.wfu.edu/handle/10339/36144 The metabolic fate of newly absorbed cholesterol and phytosterols is orchestrated through the sterol transporter, adenosine triphosphate-binding cassette transporter G5/G8 heterodimer (G5/G8), and the cholesterol esterifying enzyme, acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2). We hypothesized that, in the enterocyte, ACAT2 cholesterol esterification increases cholesterol absorption efficiency by providing the cholesterol esters (CE) for incorporation into chylomicrons and that G5/G8 limits both phytosterol and cholesterol absorption by reducing substrate availability for ACAT2 esterification. en Wake Forest University ABCG5/G8 ACAT2 Cholesterol absorption chylomicron lipoprotein metabolism thoracic lymph duct cannulation MECHANISMS OF INTESTINAL CHOLESTEROL ABSORPTION AND TRANSPORT IN MOUSE THORACIC LYMPH DUCT LIPOPROTEINS Dissertation Rudel, Lawrence L Parks, John S Kavanaugh, Kylie Brown, Jonathan M Molecular Pathology 2012-09-08 open.access