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oai:null:10339/361652026-09-02T14:36:24Zcom_10339_14934col_10339_38132

Juneau, Richard Anthony 2011-09-08T08:36:12Z 2012-09-08T08:30:06Z 2011 https://wakespace.lib.wfu.edu/handle/10339/36165 Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative commensal bacteria of the human nasopharynx. Normally residing in healthy individuals, NTHi rarely causes adverse effects. However, infection with NTHi in children often leads to middle ear inflammation and disease in the form of otitis media. A high frequency of doctor visits, antibiotic prescription, and drainage tube placement are due to childhood otitis media infections. Chronic obstructive pulmonary disease (COPD) is a restriction of airflow through the lungs and is often caused by cigarette smoking. In the United States, COPD is the fourth leading cause of death. NTHi is often found in patients suffering from COPD and it is implicated in exacerbation of disease. Since these diseases remain a health-care concern, it is important that we continue to study NTHi disease dynamics and host responses during the disease. en Wake Forest University COPD Haemophilus influenzae neutrophil extracellular trap otitis media PMN Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress Dissertation Swords, William E Reid, Sean Hiltbold-Schwartz, Elizabeth Haas, Karen Microbiology & Immunology 2012-09-08 open.access