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oai:null:10339/364292026-09-02T11:57:34Zcom_10339_14934col_10339_38132

Casina, Veronica Christine 2012-01-18T09:35:30Z 2011 https://wakespace.lib.wfu.edu/handle/10339/36429 Cellular enzymes interact with RNA substrates at several key stages in an organism's life cycle, particularly during the processes of transcription and translation. A more detailed description of enzyme mechanistic features and kinetic parameters is important both for understanding molecular function in general and as possible therapeutic targets. The two classes of RNA-interacting enzymes investigated in the work described here are helicases, which disrupt RNA secondary structure, and aminoacyl-tRNA synthetases, which catalyze the attachment of an amino acid to its cognate tRNA. en Wake Forest University Pre-steady state kinetics Prokaryote Protein biosynthesis RNA stability steady state kinetics strand displacement Kinetic and mutational studies of two RNA-interacting enzymes Dissertation Alexander, Rebecca W. Hollis, Thomas Bierbach, Ulrich Colyer, Christa King, S. Bruce Chemistry forever 10000-01-01 restricted