2026-09-21T15:07:58Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/364402026-09-02T08:39:07Zcom_10339_14934col_10339_38132

Strong, Shannon Alissa 2012-01-18T09:35:34Z 2012-01-18T09:35:34Z 2011 https://wakespace.lib.wfu.edu/handle/10339/36440 Leptin, a peptide hormone secreted by adipocytes, has been widely studied in the attempt to understand its contributions and relation to obesity. There is a sexual dimorphism in leptin levels between men and women, suggesting a possible influence of steroid hormones on leptin expression and signaling pathways. Likewise, evidence suggests that leptin gene expression is regulated by steroid hormones in humans and mice. Leptin signals through a membrane receptor, <italic>Ob-R</italic>, and expression of the Ob-R</italic> isoforms are also sexually dimorphic, and suggest that steroid hormones may also control receptor expression. The experiments described here attempt to better understand the potential relationship between steroid hormones and leptin receptor (<italic>Ob-R</italic>) gene expression. This hormonal regulation may result in leptin resistance in men and women, increasing risks for prolonged and irreversible obesity. en Wake Forest University 3T3-L1 Adipocytes Leptin Receptor Obesity qRT-PCR Steroids The Effect of Steroid Hormones on Expression of the Leptin Receptors Thesis Browne, Carole Muday, Gloria Johnson, Erik Biology open.access