2026-09-21T13:03:48Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/364432026-09-02T12:19:40Zcom_10339_14934col_10339_38132

Connolly, Kristie Lee 2012-01-18T09:35:35Z 2014-01-18T09:30:11Z 2011 https://wakespace.lib.wfu.edu/handle/10339/36443 Group A Streptococcus (GAS) is a Gram-positive human pathogen that commonly causes mild skin infections. However, GAS also causes severe infections including necrotizing fasciitis. The mechanism for triggering the switch between mild and severe disease has yet to be discovered. Several groups have shown that regulation of protease production may play a role in the transition from localized to systemic infection. GAS has evolved the ability to colonize a variety of distinct host sites, and one possible mechanism for colonization is through the formation of a biofilm. A biofilm is a structured, sessile microbial community encased in an extracellular matrix and may provide protection from the immune response and antibiotic therapy. We and others have shown that GAS is able to form biofilms <italic>in vitro<italic> and <italic>in vivo<italic>, however, the regulation and role of these structures during an infection remains unclear. en Wake Forest University Biofilms Group A Streptococcus Pathogenesis SpeB Srv SRV REGULATION OF STREPTOCOCCAL BIOFILM DISPERSAL AND ITS IMPACT ON VIRULENCE Dissertation Reid, Sean D Swords, William E Seeds, Michael Hiltbold-Schwartz, Elizabeth Kock, Nancy Microbiology & Immunology 2014-01-18 restricted