2026-09-18T19:27:31Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/364452026-09-02T10:21:16Zcom_10339_14934col_10339_38132

Ewan, Eric Edward 2012-01-18T09:35:36Z 2012-07-18T08:30:16Z 2011 https://wakespace.lib.wfu.edu/handle/10339/36445 Treatment of neuropathic pain remains a major unmet public health problem. Serious concerns arise over misuse of prescription opioids in chronic pain patients, a drug class representing the fastest growing substance abuse problem in the United States. Ascending pain pathways overlap significantly with limbic regions involved in reward and reinforcement, therefore pain and reward systems substantially interact and modulate one another. The extent to which pain modulates mesolimbic dopamine systems and thereby alters the reinforcing and abuse-related effects of opioids is not fully understood. The ability of pain relief to produce reinforcement in and of itself through modulation of this circuitry is also unknown. en Wake Forest University Behavioral Pharmacological Analysis of Deep Brain Stimulation Following Nerve Injury Dissertation Martin, Thomas J Eisenach, James C Childers, Steven R Coghill, Robert C Rauck, Richard L Roberts, David C Physiology and Pharmacology 2012-07-18 open.access