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oai:null:10339/372512026-09-02T09:13:52Zcom_10339_14934col_10339_38132

Banerjee, Papri 2012-06-12T08:35:42Z 2014-06-12T08:30:07Z 2012 https://wakespace.lib.wfu.edu/handle/10339/37251 Proteins are dynamic macromolecules. According to Koshland's classical "induced fit" model of enzyme regulation, proteins have essential conformational flexibility for ligand binding, which promotes catalysis by structural rearrangement. Proteins undergo structural rearrangements to bind ligands, regulate access to a catalytic site, or release products. The energetic contribution of protein flexibility to catalysis is not well understood, despite numerous high resolution crystal structures available for numerous proteins bound with their corresponding ligands. en Wake Forest University Investigating the Role of Conformational Flexibility in tRNA Aminoacylation Dissertation Alexander, Rebecca W Cho, Samuel Bierbach, Ulrich Colyer, Christa Dos Santos, Patricia Chemistry 2014-06-12 restricted