2026-09-20T19:11:53Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/373012026-09-02T10:15:20Zcom_10339_14934col_10339_38132

Mazanka, Paul James 2012-06-12T08:36:04Z 2012 https://wakespace.lib.wfu.edu/handle/10339/37301 <bold>INTRODUCTION:</bold> Children born preterm and with very low birth weight are at increased risk of developing elevated blood pressure (BP) later in life. One mechanism of short-term BP regulation is the baroreflex, which can be assessed by calculating baroreflex sensitivity (BRS). There is evidence in animals that the baroreflex may play a role in regulating BP on a long-term basis, but evidence is lacking in humans, particularly children. <bold>PURPOSE:</bold> To examine relationships between short-term measures of baroreflex function (i.e. BRS) and long-term ambulatory BP and variability in a cohort of children born with very low birth weight. <bold>METHODS:</bold> Spontaneous BRS was measured during 10 minutes of supine rest using a Continuous Non-Invasive Arterial Pressure (CNAP) Monitor 500. Nevrokard software calculated BRS using the sequence method (BRSseq) and spectral method (LFα). Ambulatory BP monitoring took place over a 24-hour period. Data were analyzed separately for awake and asleep periods. Variability was calculated as standard deviations (SD) for awake and asleep and a weighted SD for the 24-hour period. Relationships between measures of BRS and ambulatory BP were examined using correlational analysis. <bold>RESULTS:</bold> A total of 33 participants (22 female, 11 male) had both BRS and ambulatory BP data. Mean BRS values were 24.2 ± 20.4 ms*mmHg-1 for BRSseq and 23.3 ± 12.7 ms*mmHg-1 for LFα. Mean absolute ambulatory SBP/DBP for the 24-hour period was 115.4/66.9. Mean ambulatory BP variability was 9.1 ± 17 mmHg for the 24-hour period. Negative correlations were found between BRSseq and both 24-hour SBP (r=-.336, p=.087) and asleep SBP (r=-.370, p=.053). There were no significant relationships between BRS and ambulatory BP variability. <bold>CONCLUSION:</bold> The results revealed that BRS accounted for 11-14% of the shared variance in ambulatory SBP suggesting that the baroreflex likely plays at least a partial role in regulating BP on a long-term basis in preterm, VLBW adolescents who are at risk for developing hypertension. en Wake Forest University baroreceptors baroreflex blood pressure regulation low birth weight Role of the Baroreflex in Long-Term Blood Pressure Regulation in Children Born With Very Low Birth Weight Thesis Nixon, Patricia A Brubaker, Peter H Washburn, Lisa K Health and Exercise Science forever 10000-01-01 restricted