2026-09-21T19:40:47Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/374422026-09-02T12:32:31Zcom_10339_14934col_10339_38132

Schnegg, Caroline Isabel 2012-09-05T08:35:20Z 2012-09-05T08:35:20Z 2012 https://wakespace.lib.wfu.edu/handle/10339/37442 As a result of improvements in cancer therapy and health care, the population of long-term cancer survivors is growing. For these approximately 12 million long-term cancer survivors, brain metastases are a significant risk. Fractionated partial or whole-brain irradiation (fWBI) is often required to treat both primary and metastatic brain cancer. Radiation-induced normal tissue injury, including progressive cognitive impairment, however, can significantly affect the well-being of the approximately 200,000 patients who receive these treatments each year. Recent reports indicate that radiation-induced brain injury is associated with chronic inflammatory and oxidative stress responses, as well as increased microglial activation in the brain. Anti-inflammatory drugs may, therefore, be a beneficial therapy to mitigate radiation-induced brain injury. We hypothesized that activation of peroxisomal proliferator activated receptor delta (PPARä) would prevent or ameliorate radiation-induced brain injury, including cognitive impairment, in part, by alleviating inflammatory responses in microglia. en Wake Forest University Inflammation PPARdelta Radiation-Induced Brain Injury RADIATION-INDUCED INFLAMMATORY MARKERS OF BRAIN INJURY ARE MODULATED BY PPARä ACTIVATION IN VITRO AND IN VIVO Dissertation Robbins, Michael E Townsend, Alan J Sui, Guangchao Chan, Michael D Cancer Biology open.access