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Manring, Heather Renee 2013-01-09T09:35:14Z 2015-01-09T09:30:09Z 2012 https://wakespace.lib.wfu.edu/handle/10339/37663 The Wnt/Beta-catenin signaling pathway has many roles including regulation of developmental pathways, cell proliferation, and homeostasis of adult tissues. Wnt/Beta-catenin signaling activity depends on the stability and localization of Beta-catenin in the cell. In the absence of a Wnt-signal, Beta-catenin, which plays an integral role as a cell adhesion adapter protein and as a transcriptional coregulator, is phosphorylated by GSK3 Beta; in a complex with APC, AXIN, and CK1. Phosphorylation promotes ubiquitination of Beta-catenin and subsequent proteasomal degradation. When a Wnt-ligand binds to a Frizzled receptor, a signaling cascade displaces GSK3 Beta from its complex with Beta-catenin allowing Beta-catenin protein to accumulate and translocate to the nucleus. In the nucleus, Beta-catenin activates transcription of its target genes by binding TCF/LEF transcription factors. Aberrant Wnt/Beta-catenin signaling activity leads to misregulation of proliferation and metabolic pathways and has been linked to a number of diseases. en Wake Forest University Beta-catenin cancer diabetes Wnt COMPARATIVE CELL BASED FUNCTIONAL ANALYSIS OF KEY WNT/BETA-CATENIN PATHWAY GENES AND GENE MUTATIONS Dissertation Antinozzi, Peter A Miller, Lance Torti, Suzy Townsend, Alan Wilkinson, John Biochemistry and Molecular Biology 2015-01-09 restricted