2026-09-21T02:53:44Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/390302026-09-18T13:52:07Zcom_10339_14934col_10339_38132

Stone, Austin V. 2013-08-23T08:35:19Z 2014-02-23T09:30:12Z 2013 https://wakespace.lib.wfu.edu/handle/10339/39030 The overarching goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in established osteoarthritis, characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development. en Wake Forest University cartilage chemokine cytokine meniscus MMP osteoarthritis A potential biologic role for the meniscus in the development of osteoarthritis. Dissertation Ferguson, Cristin M Loeser, Richard F Yammani, Raghunatha R Callahan, Michael F Van Dyke, Mark E Molecular Medicine and Translational Science 2014-2-23 open.access