2026-09-19T21:37:16Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/391092026-09-02T08:23:03Zcom_10339_14934col_10339_38132

Zimmer, Benjamin A. 2014-01-15T09:35:18Z 2014-01-15T09:35:18Z 2013 https://wakespace.lib.wfu.edu/handle/10339/39109 The complex set of symptoms associated with substance use disorder has made creating animal models with high predictive validity difficult. One tactic to help translate results from animal studies to humans is to separate the symptoms of substance use disorder into two broad categories of dysregulated drug taking and dysregulated drug seeking. However, distinguishing the drug seeking or drug taking components in self-administration models can be difficult since the consumptive and appetitive responses are both directed towards the same operant. A variety of analysis methods, procedures, and schedules of reinforcement can be used to help separate the conflated consumptive vs appetitive aspects of self-administration, and distinguishing these characteristics represents a unique lens with which to examine results from self-administration studies. en Wake Forest University appetitive cocaine consumptive drug-seeking drug-taking self-administration Behavioral Models of Cocaine Use Disorder Dissertation Roberts, David CS Stanford, Terrance R Jones, Sara R McCool, Brian A Weiner, Jeffrey L Neuroscience open.access