2026-09-21T12:11:08Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/391172026-09-02T11:25:13Zcom_10339_14934col_10339_38132

Lenhausen, Audrey May 2014-01-15T09:35:21Z 2014-07-15T08:30:09Z 2013 https://wakespace.lib.wfu.edu/handle/10339/39117 Apoptosis-inducing factor (AIF) is a mitochondrial NADH-oxidase originally discovered for its ability to trigger apoptosis through chromatin condensation and DNA cleavage. Although AIF is recognized for its apoptotic function, AIF-mediated cell death has emerged as an atypical cell death pathway; and accumulating evidence indicates AIF to play a more significant role in cell survival by maintaining mitochondrial homeostasis. A loss in AIF protein leads to a variety of mitochondria-specific alterations, including defects in mitochondrial structure, alteration to mitochondrial fission and fusion dynamics, and decreases to the protein complement of the electron transport chain resulting in diminished oxidative phosphorylation. Along with the ability to promote healthy mitochondrial function, AIF has demonstrated a supportive role in cancer cell growth which may be connected to its ability to regulate mitochondrial metabolism. The mechanisms governing how AIF impacts various mitochondrial features are unknown, and a concomitant role for deregulated AIF activity in human disease, in particular cancer, is poorly defined. en Wake Forest University THE PROSURVIVAL ACTIVITIES OF APOPTOSIS-INDUCING FACTOR CONVERGE UPON THE REGULATION OF MITOCHONDRIAL METABOLISM, A NOVEL CELL DEATH PATHWAY, AND THE PROGRESSION OF PROSTATE CANCER Dissertation Wilkinson, John Kridel, Steve Daniel, Larry Poole, Leslie Wang, Yuh-Hwa Biochemistry and Molecular Biology 2014-7-15 open.access