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oai:null:10339/391312026-09-18T12:03:25Zcom_10339_14934col_10339_38132

Turner, Roberta Lynn 2014-01-15T09:35:34Z 2014-01-15T09:35:34Z 2013 https://wakespace.lib.wfu.edu/handle/10339/39131 A productive adenovirus infection inundates the host cell with linear, double-stranded DNA molecules and an abundance of single-stranded DNA. The cellular responses of cell death and cell cycle arrest to this apparent profusion of damaged DNA are antagonized by overlapping activities encoded in the adenoviral E1B and E4 early genes. A mutant group C adenovirus that fails to express the E1B-55K and E4ORF3 genes is unable to suppress the DNA-damage response. Cells infected with this double-mutant virus display significant morphological heterogeneity at late times of infection. Fragmented nuclei and mitotic arrest frequently contribute to this heterogeneity. en Wake Forest University Adenovirus AIF cell cycle cell death DNA damage oncolytic virus E1B and E4 adenoviral oncoproteins modulate cellular responses to DNA damage Dissertation Ornelles, David A Lyles, Douglas S Alexander-Miller, Martha Parks, Griffith D Wilkinson, John C Microbiology & Immunology open.access