2026-09-21T00:26:40Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/393262026-09-02T14:52:13Zcom_10339_14934col_10339_38132

Bonomo, Jason A. 2014-07-10T08:35:42Z 2015-01-10T09:30:09Z 2014 https://wakespace.lib.wfu.edu/handle/10339/39326 There is strong clinical and epidemiological evidence supporting a genetic link between type 2 diabetes associated end-stage kidney disease (T2D-ESKD) and African ancestry. Incidence and prevalence of T2D-ESKD, in addition to non-diabetic forms of ESKD, are markedly higher in African Americans compared to all other ethnicities even after adjustment for socioeconomic factors. Familial aggregation studies also support a strong genetic component to T2D-ESKD in African Americans. In this series of studies we examined this health care disparity from a genetics perspective by leveraging state-of-the-art genetic methodologies, including whole exome sequencing and bioinformatic tools, in an effort to further elucidate the genetic architecture of T2D-ESKD and non-T2D ESKD in several samples of African Americans, and to a lesser extent, in European Americans. en Wake Forest University diabetic nephropathy end-stage kidney disease end-stage renal disease low-frequency coding variants nephrin RREB1 Evaluation of Genetic Variants Influencing Susceptibility to Type 2 Diabetes Associated End-Stage Kidney Disease and Associated Phenotypes Dissertation Bowden, Donald W Allred, Nichollete P Ng, Maggie CY Howard, Timothy D Molecular Medicine and Translational Science 2015-1-10 open.access