2026-09-20T03:38:12Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/393342026-09-18T14:17:58Zcom_10339_14934col_10339_38132

Blume, Lawrence Christopher 2014-07-10T08:35:44Z 2015-07-10T08:30:11Z 2014 https://wakespace.lib.wfu.edu/handle/10339/39334 Cannabis, or marijuana, is the most commonly used illicit drug in the United States. The CB1 cannabinoid receptor (CB1R) has been extensively studied since the initial characterization of its involvement in mediating the psychotropic effects of marijuana. CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in the CNS and has been targeted therapeutically for multiple diseases; however side effect profiles for CB1R have posed difficulty in the development of clinically successful CB1R drugs. The identification of GPCR interacting proteins has provided additional insight into the fine-tuning and regulation of numerous GPCR's. The Cannabinoid Receptor Interacting Protein 1a (CRIP1a) binds to the extreme carboxy terminus of CB1R, and has been shown to alter CB1R-mediated neuronal function. The mechanisms by which CRIP1a regulates CB1R activity and trafficking have not yet been identified; therefore the focus of this dissertation is to examine the cellular effects of CRIP1a on CB1R function and cellular trafficking. en Wake Forest University B-ARRESTIN CB1R CRIP1A GPCR SIGNALING CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION Dissertation Howlett, Allyn C Lowther, Todd Childers, Steven R. Chen, Rong Selley, Dana E. Physiology and Pharmacology 2015-07-10 open.access