2026-09-22T22:00:08Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/571362026-09-02T14:07:57Zcom_10339_14934col_10339_38132

Cook, Guerry 2015-06-23T08:35:49Z 2015-12-22T09:30:10Z 2015 https://wakespace.lib.wfu.edu/handle/10339/57136 Acute Myeloid Leukemia (AML) is an aggressive disease of the marrow with approximately 18,800 new cases each year. The elderly population represents the bulk of AML patients with a median age of onset of 70. More than 70% of AML patients are over the age of 60, and for this group the 5 year overall survival rate is under 10%. There are multiple reasons for this, including complex karyotypes in elderly patients, other comorbidities, and chemoresistance. This group of patients needs more effective chemotherapeutic options. en Wake Forest University Acute Myeloid Leukemia Azacitidine Decitabine Didox Preclinical Ribonucleotide Reductase Studies of the efficacy of Ribonucleotide Reductase inhibition in preclinical models of Acute Myeloid Leukemia in combination with standard and novel therapeutics Dissertation Pardee, Timothy S Seals, Darren Gmeiner, William Wadas, Thaddeus Cancer Biology 2015-12-22 open.access