2026-09-21T21:17:51Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/572592026-09-02T09:43:10Zcom_10339_14934col_10339_38132

Guan, Xuan 2015-08-25T08:35:32Z 2016-08-24T08:30:10Z 2015 https://wakespace.lib.wfu.edu/handle/10339/57259 Dystrophin deficient cardiomyopathy is a hereditary disorder resulting from dystrophin gene mutation. All patients inevitably develop cardiomyopathy and 30%-50% of them succumb to congestive heart failure. The mechanism of dystrophic cardiomyopathy is still elusive, partly due to the scarce human material to study this disease. Therefore, we propose to create dystrophin deficient cardiomyopathy in vitro using DMD patient cardiomyocytes derived from induced pluripotent stem cells (iPSC). By converting adult somatic cells to iPSCs and further differentiate into cardiac lineage, a vast number of cardiomyocytes can be manufactured to explore disease etiology and conduct drug screening. en Wake Forest University adeno associated virus Cellular Reprogramming Drug Evaluation Preclinical Genetic Therapy Induced Pluripotent Stem Cells Muscular Dystrophy Duchenne MODELING HEART DISEASE OF PATIENTS WITH MUSCULAR DYSTROPHY USING INDUCED PLURIPOTENT STEM CELLS Dissertation Childers, Martin K Herrington, David M Christ, George J Furth, Mark E Froehner, Stanley C Physiology and Pharmacology 2016-08-24 open.access