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oai:null:10339/572662026-09-18T12:05:41Zcom_10339_14934col_10339_38132

LI, WEI 2015-08-25T08:35:35Z 2017-08-24T08:30:13Z 2015 https://wakespace.lib.wfu.edu/handle/10339/57266 Fibrinogen, one of the most abundant proteins in blood plasma, plays a central role in hemostasis and thrombotic disease. In the final step of the coagulation cascade, thrombin proteolytically converts fibrinogen to fibrin, which then forms a mesh of fibrin fibers. This mesh is the major structural component of a blood clot. Over the last few years the mechanical properties of fibrin fibers, such as their modulus, elasticity and extensibility, have been determined using samples formed from purified fibrinogen. In my work, presented in this dissertation, I initiated study on the more complex and more physiologically relevant fibrin fibers formed from plasma samples, in an effort to find relationships between single fibrin fiber mechanical properties and disease states. en Wake Forest University fibrin fiber lysis mechanical property Single Fibrin Fiber Mechanical Properties and Lysis Dissertation Guthold, Martin Marrs, Glen Bonin, Keith Macosko, Jed Williams, Richard Physics 2017-08-24 open.access