2026-09-19T21:37:17Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/572692026-09-02T13:45:11Zcom_10339_14934col_10339_38132

Clodfelter, William Howard Craig 2015-08-25T08:35:36Z 2016-08-24T08:30:10Z 2015 https://wakespace.lib.wfu.edu/handle/10339/57269 Nitric oxide (NO) is an important cellular signaling molecule known mostly for its vasodilatative effects. Nitrate (NO3-) acts as an important NO source through reductive physiological pathways. Basal plasma NO3- levels are a sum of the oxidation of endogenous NO and ingested dietary NO3-. Approximately 25% of dietary NO3- is recovered by the salivary glands and concentrated up to 20-fold in saliva. Humans possess symbiotic NO3- reductase activity from the anaerobic bacteria (Actinomyces and Veillonella) species found in the tongue’s cleft. Preliminary genomic analyses of these species indicate the lack of nitrite (NO2-) reductase ortholog genes suggesting dissimilatory NO3- reduction. The goal of Aim 1 of this research was to investigate and fully characterize the reduction of dietary NO3- to reduced nitrogen oxides in the oral cavity. en Wake Forest University Dietary Nitrate Nitrate Nitric Oxide Nitrite Nitrogen Oxide Saliva Salivary Reduction of Dietary Nitrate Dissertation King, Stephen B Kim-Shapiro, Daniel Welker, Mark E DosSantos, Patricia Bierbach, Ulrich Chemistry 2016-08-24 open.access