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Millet, Patrick 2016-01-11T09:35:18Z 2016-07-10T08:30:10Z 2015 https://wakespace.lib.wfu.edu/handle/10339/57421 Sepsis is serious medical condition which kills millions of people worldwide each year. In the United States, severe sepsis has a mortality rate of 20-30%, with an annual cost of over $25 billion. Modern advances in supportive care have brought the mortality rate down to its current level, however there is currently no molecular-based treatment available for sepsis. Many treatments have been tested in clinical trials, but none have proven reliably beneficial. These treatments, however, seldom accounted for the fact sepsis has distinct stages with distinct immunometabolic profiles. Early sepsis is marked by inflammation and glycolysis, while late sepsis is marked by immune suppression and fatty acid oxidation. As an increasing body of data suggests, these metabolic and immune states may be interdependent. en Wake Forest University Inflammation Metabolism Mitochondria Monocytes RNA biology Sepsis INTERDEPENDENT REGULATION OF METABOLISM AND INFLAMMATION IN HUMAN MONOCYTES Dissertation McCall, Charles E McPhail, Linda Yoza, Barbara Alexander-Miller, Martha Molina, Anthony Molecular Genetics & Genomics 2016-07-10 open.access