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Siciliano, Cody A. 2016-01-11T09:35:28Z 2018-01-10T09:30:10Z 2015 https://wakespace.lib.wfu.edu/handle/10339/57442 The behavioral and neurochemical effects of amphetamine have been studied since the beginnings of neuroscience; however, many questions still remain as to its precise mechanisms of action on neurotransmission, and the resulting effects on behavior. Given that amphetamine is one of the most widely prescribed stimulants, and is also abused off-label, it is critical to understand the mechanisms of amphetamine actions to drive the design of improved pharmacotherapeutics with high clinical efficacy and limited addiction potential. The work contained in this dissertation is focused on elucidating amphetamine’s actions on dopamine neurotransmission that underlie its therapeutic actions as well as its abuse potential. en Wake Forest University addiction behavioral economics dopamine nucleus accumbens self-administration voltammetry ELUCIDATING AMPHETAMINE ACTIONS AT THE DOPAMINE TERMINAL: POTENTIAL FOR COCAINE ADDICTION TREATMENT Dissertation Jones, Sara R Martin, Thomas J Porrino, Linda J McCool, Brian A Nader, Michael A Weiner, Jeffrey L Physiology and Pharmacology 2018-01-10 open.access