2026-09-20T02:20:31Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/592632026-09-18T12:41:09Zcom_10339_14934col_10339_38132

Metzler, Marnie Silverstein 2016-05-21T08:35:29Z 2016-05-21T08:35:29Z 2016 https://wakespace.lib.wfu.edu/handle/10339/59263 Selective serotonin reuptake inhibitor (SSRI) antidepressants, widely prescribed for depression and other disorders, have been associated with increased ischemic stroke risk in several observational studies. Previously the Shively lab has reported that long-term SSRI treatment and depression independently increased coronary artery atherosclerosis; however effects on carotid artery atherosclerosis, a precursor to ischemic stroke, are unknown. Whether SSRI use affects risk factors for stroke and atherosclerosis is also unclear as results from clinical trials and observational studies are mixed. The overall objective of this dissertation research was to determine the effects of long-term SSRI treatment on carotid artery atherosclerosis and associated risk factors using a translational nonhuman primate model of depression. en Wake Forest University atherosclerosis depression monkey nonhuman primate SSRI stroke Effects of Chronic Selective Serotonin Reuptake Inhibitor Use on Carotid Artery Atherosclerosis Dissertation Shively, Carol A Nader, Michael A Appt, Susan E Caudell, David L Register, Thomas C Physiology and Pharmacology open.access