2026-09-20T03:59:06Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/592742026-09-18T12:48:06Zcom_10339_14934col_10339_38132

Bolduc, Jesalyn 2016-05-21T08:35:36Z 2018-05-20T08:30:11Z 2016 https://wakespace.lib.wfu.edu/handle/10339/59274 Prxs are a family of antioxidant proteins that are the predominant peroxidase within the cell. This thesis research focuses on the structure and biochemistry of peroxiredoxins (Prx) and their sensitivity to inactivation by their own substrate, in a process called hyperoxidation. Hyperoxidation sensitivity is important to study because Prxs are implicated in many different diseases. For example, Prxs contribute to chemo- and radioresistance in cancers, so by sensitizing a Prx to inactivation, it may be possible to resensitize cancer cells to therapy. en Wake Forest University crystallography kinetics oxidative stress peroxiredoxins redox biology signaling Studies in Peroxiredoxin Hyperoxidation Sensitivity Dissertation Lowther, W. Todd Hollis, Thomas Poole, Leslie Lyles, Douglas Biochemistry and Molecular Biology 2018-05-20 open.access