2026-09-20T07:53:18Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/592912026-09-02T16:27:03Zcom_10339_14934col_10339_38132

McKay, Jerome Thomas 2016-05-21T08:35:41Z 2021-05-04T08:30:12Z 2016 https://wakespace.lib.wfu.edu/handle/10339/59291 Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an in-depth understanding of the role of PD-1 and PD-1 ligands (PD-L) in B cell regulation. This dissertation specifically ascertains the role of PD-1 and PD-L in the regulation of natural Ab production and also adaptive Ab responses to T cell-independent type 2 (TI-2) antigens (Ag). en Wake Forest University B-1 cells PD-1 PD-L1 PD-L2 Phosphorylcholine Polysaccharide PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES Dissertation Haas, Karen M Claiborne, Al Deora, Rajendar Alexander-Miller, Martha Swords, William Edward Microbiology & Immunology 2021-05-04 open.access