2026-09-21T16:31:07Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/626312026-09-02T16:18:33Zcom_10339_14934col_10339_38132

Ortega, Victor Enrique 2016-08-25T08:35:19Z 2021-08-18T08:30:13Z 2016 https://wakespace.lib.wfu.edu/handle/10339/62631 Background: Genetic studies in asthma and COPD have identified common genetic variants that explain a small proportion of inter-individual variability in drug response and severity. Genetic ancestry could be associated with disease severity in individuals from recently admixed ethnic groups, such as African Americans where a higher percentage of African ancestry was associated with lower lung function. Rare genetic variants (allele frequency <0.05) with strong effects and genetic ancestry have the potential to be genetic factors that determine drug response and severity in asthma and COPD. en Wake Forest University asthma COPD genetics pharmacogenetics rare variant single nucleotide polymorphism THE EFFECTS OF RARE GENETIC VARIANTS AND GENETIC ANCESTRY ON DRUG RESPONSE AND SEVERITY IN AIRWAYS DISEASES Dissertation Meyers, Deborah A Bleecker, Eugene R Hawkins, Gregory A Bowden, Donald W Howard, Timothy D Molecular Medicine and Translational Science 2021-08-18 open.access