2026-09-21T20:24:04Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/626322026-09-18T11:56:08Zcom_10339_14934col_10339_38132

Smelser, Amanda M. 2016-08-25T08:35:19Z 2016-08-25T08:35:19Z 2016 https://wakespace.lib.wfu.edu/handle/10339/62632 Unlike their normal counterparts, breast cancer cells break free from epithelia and invade the underlying stroma, leading to deadly metastases. Cell migration requires mechanical interactions between the intracellular cytoskeleton and the extracellular matrix. The goals of this work were to compare mechanical properties of metastatic and non-metastatic cells, and to develop a method for testing the effect of microenvironment elasticity on cancer cell migration. en Wake Forest University breast cancer cells collagen elasticity mechanical properties microrheology migration Breast Cancer Cell Mechanical Properties and Migration on Collagen I Matrices with Tunable Elasticity Dissertation Macosko, Jed C Cho, Samuel S Lyles, Doug S Hantgan, Roy Biochemistry and Molecular Biology open.access