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oai:null:10339/641712026-09-02T13:16:10Zcom_10339_14934col_10339_38132

Gioia, Dominic Andrew 2017-01-14T09:35:17Z 2018-01-13T09:30:09Z 2016 https://wakespace.lib.wfu.edu/handle/10339/64171 Alcoholism is a chronically relapsing disorder characterized by an inability to remain abstinent from alcohol for prolonged periods of time. One of the major factors contributing to relapse is the development of profound anxiety during abstinence. Our lab has previously demonstrated that chronic exposure to alcohol and subsequent withdrawal leads to long-term adaptations in glutamatergic transmission within the basolateral amygdala (BLA). We have also demonstrated that this hyperexcitable state contributes to the expression of withdrawal related anxiogenesis and can be ameliorated by glutamatergic antagonists. However, it remains unclear how acute exposure to alcohol produces long-term changes in BLA glutamatergic transmission. en Wake Forest University Alcohol anxiety basolateral amygdala glutamate Munc13 Presynaptic MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING Dissertation McCool, Brian A Stanford, Terrence Jones, Sara Martin, Thomas J Weiner, Jeff Neuroscience 2018-01-13 open.access