2026-09-22T04:35:34Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/821602026-09-18T13:08:05Zcom_10339_14934col_10339_38132

Gao, Chuan 2017-06-15T08:35:29Z 2019-06-14T08:30:13Z 2017 https://wakespace.lib.wfu.edu/handle/10339/82160 Cardiometabolic syndrome (CMS) is a clustering of interrelated risk factors (central obesity, hyperglycemia, hypertension, insulin resistance, and dyslipoproteinemia) that promotes the development of atherosclerotic vascular disease and type 2 diabetes. It was recognized as a disease entity by the American Society of Endocrinology, National Cholesterol Education Program (NCEP), and World Health Organization in 2003 (Castro, El-Atat, McFarlane, Aneja, & Sowers, 2003). Previous genetic studies with monozygotic and dizygotic twin pairs suggested a strongly heritable pattern for CMS risk factors, i.e. it is estimated that circulating lipid heritability ranges from 0.58 to 0.66 (h2HDL=0.61, h2LDL=0.59, h2TC=0.58, h2TG=0.66) (Knoblauch et al., 1997). However, the exact genetic mechanism of the disease is poorly understood. en Wake Forest University Cardiometabolic syndrome Genetics GWAS Mexican Americans INVESTIGATION OF THE GENETIC ARCHITECTURE OF CARDIOMETABOLIC DISEASE Dissertation Allred, Nicholette D. Langefeld, Carl D. Bowden, Donald W. Parks, John S. Liu, Yongmei Molecular Genetics & Genomics 2019-06-14 open.access