2026-09-20T18:53:06Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/822412026-09-02T16:27:18Zcom_10339_14934col_10339_38132

Mauney, Christopher Holbrook 2017-06-15T08:36:12Z 2019-06-14T08:30:14Z 2017 https://wakespace.lib.wfu.edu/handle/10339/82241 The purpose of this study was to investigate the regulation of SAMHD1 and its relation to nucleotide metabolism and cell cycle progression. Phosphorylation of SAMHD1 is the most extensively documented means of regulation. While questions still remain regarding regulation of SAMHD1 by phosphorylation, this work investigates an alternative mechanism of regulation. A major signaling pathway that has not been investigated with regards to SAMHD1 regulation is redox biology. Redox biology is emerging as a central regulator in myriad cellular processes including cell cycle progression, cellular metabolism, and cell signaling. Given the role that nucleotide metabolism plays in these processes, this study was undertaken to test the hypothesis that SAMHD1 is a redox regulated enzyme and that redox signaling is important for modulating SAMHD1 activity in vivo. en Wake Forest University Aicardi-Goutieres cell cycle deoxynucleotide triphosphate HIV Redox SAMDH1 AN INVESTIGATION OF THE REDOX REGULATION OF THE DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE SAMHD1 AND ITS ROLE IN NUCLEOTIDE HOMEOSTASIS Dissertation Hollis, Thomas J Alexander, Rebecca Lowther, W. Todd Lyles, Doug Ornelles, David Perrino, Fred Biochemistry and Molecular Biology 2019-06-14 open.access