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Poole, Thomas 2017-06-15T08:36:18Z 2018-06-14T08:30:13Z 2017 https://wakespace.lib.wfu.edu/handle/10339/82253 Sulfenic acids are fleeting intermediates formed from the oxidation of cysteine thiols by a number of biologically relevant oxidants. Sulfenic acids are quickly converted to other species including disulfides, thiosulfinates, sulfinic acids, or sulfonic acids, leading to changes in protein function. The resulting structural and functional changes can modulate enzyme activity, activate transcription factors, and lead to signaling cascades. Understanding the intricacies of sulfenic acid signaling is important for understanding healthy cellular function and disease states. Identifying the site, timing, and conditions of protein sulfenic acid formation is crucial to understanding cellular redox regulation. en Wake Forest University Click Dimedone Peroxiredoxin Signaling Sulfenic Acid Thiol UNDERSTANDING SULFUR BASED REDOX BIOLOGY THROUGH ADVANCEMENTS IN CHEMICAL BIOLOGY Dissertation King, Stephen Bruce Poole, Leslie B. Dos Santos, Patricia C. Jones, Paul B. Welker, Mark E. Chemistry 2018-06-14 open.access