2026-09-21T19:40:46Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/863322026-09-02T11:33:46Zcom_10339_14934col_10339_38132

Zarifpour, Mona 2017-08-22T08:35:19Z 2019-08-21T08:30:10Z 2017 https://wakespace.lib.wfu.edu/handle/10339/86332 The repair potential of the mammalian bladder has been known for over a century, but very few studies have examined the extent of bladder regeneration using animal models. The aim of the present studies was to develop a model of bladder regeneration in mice with specific emphasis on restoration of function. The impacts of immune response and a permissive microenvironment were also evaluated. Removal of a large portion of the urinary bladder (subtotal cystectomy; STC) in adult mice initiated a proliferative response that eventually gave rise to normal bladder wall architecture, including nerves, vessels, urothelium, and smooth muscle. Regenerated bladders displayed a normal low pressure, high capacity function, and were able to empty completely 12 weeks after cystectomy. Magnetic Resonance Imaging revealed a progressive increase in the bladder capacity and was able to predict the rate of bladder growth that resulted in normal function. InCITE, a combined optical tissue clearing method and computational analysis approach enabled a qualitative and quantitative exploration of the relationship between smooth muscle cell and extracellular matrix fiber morphometrics and functional recovery during repair. en Wake Forest University ESTABLISHING A MODEL OF ORGAN REGENERATION IN THE YOUNG MAMMAL: Manipulating and Developing a Permissive Microenvironment Dissertation Marini, Frank Hall, Adam Almedia Porada, Graca Christ, George Physiology and Pharmacology 2019-08-21 open.access