2026-09-20T07:35:51Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/863362026-09-02T12:40:16Zcom_10339_14934col_10339_38132

Kengla, Carlos Vinicio 2017-08-22T08:35:22Z 2018-02-21T09:30:12Z 2017 https://wakespace.lib.wfu.edu/handle/10339/86336 Tissue Engineering and Regenerative Medicine fields of life science and engineering strive to address medical challenges to human flourishing. Innovative research has led to many advances in the past two centuries with regards to treatment of orthopaedic trauma, but better options for treatment of bone injuries resulting in bony defects are still needed. Autologous bone grafts remain the standard treatment for segmental defects and non-unions. Engineered bone graft substitutes have failed to promote sufficient bone formation in large defects. The work presented here aims to prove a new platform for engineering bone tissue using 3D bioprinting strategy has the capability of combining multiple clinically relevant biomaterials in biomimetic designs to improve outcomes for engineered bone graft substitutes. The aim of these explorations is to move outcomes toward clinical use and patient benefit. en Wake Forest University bioprinting bone bone graft substitute personalized medicine tissue engineering TOWARDS PERSONALIZED BONE TISSUE ENGINEERING: CLINICALLY INSPIRED APPLICATION OF 3D BIOPRINTING Dissertation Lee, Sang Jin Downs, Brian W Yoo, James J Skardal, Aleksander Goldstein, Aaron S Biomedical Engineering 2018-02-21 open.access