2026-09-20T20:41:10Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/907682026-09-02T11:53:40Zcom_10339_14934col_10339_38132

Mayhugh, Rhiannon Elaine 2018-05-24T08:36:21Z 2019-05-23T08:30:11Z 2018 https://wakespace.lib.wfu.edu/handle/10339/90768 The importance of prevention in alcoholism is underscored by relapse rates as high as 70%. Although further development of addiction treatment remains a high priority, equally important is advancement in prevention. In this regard, attention is warranted on the neural and behavioral markers of vulnerability to transitioning from controlled drinking to AUD. Indeed, the majority of research to date has focused on alcohol dependen¬cy. Much less work has focused on a lifestyle including regular alcohol use without a history of AUD. The goal of this dissertation was to provide a step forward in the field of prevention research by studying individuals who exhibit moderate to heavy alcohol consumption (averaging 2.3 servings, 6 days per week). The specific aims were to evaluate the impact of imposed alcohol abstinence and normal drinking routines on stress and craving and to examine whether craving and brain connectivity are moderated by patterns of cardiac vagal tone. en Wake Forest University alcohol autonomic nervous system craving ecological momentary assessment fMRI stress EFFECTS OF ALCOHOL ABSTINENCE ON CRAVING, STRESS, AND NEUROBIOLOGICAL FUNCTIONING IN MODERATE TO HEAVY ALCOHOL CONSUMERS Dissertation Laurienti, Paul J Simpson, Sean L Burdette, Jonathan H McCool, Brian Rejeski, W. Jack Neuroscience 2019-05-23 open.access