2026-09-20T11:16:37Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/923802026-09-18T14:22:31Zcom_10339_14934col_10339_38132

Warner, Harleigh Jane 2018-08-23T08:35:38Z 2019-08-22T08:30:13Z 2018 https://wakespace.lib.wfu.edu/handle/10339/92380 Autologous saphenous vein is the standard material for bypassing atherosclerosed small diameter (< 6 mm) coronary arteries, but is subject to intimal hyperplasia, thrombosis, and accelerated atherosclerosis. To date, no biomaterial functions as a substitute for autologous vein graft. A novel composite material composed of electrospun poly(glycerol sebacate), silk fibroin, and type I collagen (PFC) has properties ideal for use as a tissue engineered scaffold for an artery graft. The long-term goal of this project was to develop a functionalized PFC scaffold for use as a small diameter vascular graft that would facilitate cellular infiltration and aid in the recruitment of circulating endothelial progenitor cells. To achieve this goal, three aims were identified to develop the material to be more suitable for vascular grafting en Wake Forest University FUNCTIONALIZATION OF A NOVEL ELASTOMERIC BIOMATERIAL FOR VASCULAR TISSUE ENGINEERING Dissertation Wagner, William D Goldstein, Aaron Jordan, James Whittington, Abby Skardal, Aleksander Biomedical Engineering 2019-08-22 open.access