2026-09-18T18:31:28Zhttps://wakespace.lib.wfu.edu/server/oai/request

oai:null:10339/939052026-09-02T10:12:59Zcom_10339_14934col_10339_38132

Patil, Pooja 2019-05-24T08:35:29Z 2020-05-23T08:30:17Z 2019 https://wakespace.lib.wfu.edu/handle/10339/93905 Hypertension affects over 50% of adults in the United States and is a risk factor for cardiac hypertrophy, stroke, myocardial infarction, and heart failure. If high blood pressure is untreated, damage to the myocardium and vasculature occurs, resulting in pathological fibrosis, hypertrophy, and inflammation. Polyphenols have antioxidant and anti-inflammatory properties and are beneficial against cardiovascular risk. Muscadine grapes are native to the Southeastern US and their skins and seeds are abundant in polyphenols including ellagic acid, gallic acid, and catechins. Previous studies demonstrated that muscadine grapes reduce cell proliferation and decrease inflammation. In these studies, we investigated the effects of a muscadine grape extract (MGE) on angiotensin II (Ang II)-induced hypertension and the resulting cardiac and vascular damage. en Wake Forest University cardiac fibrosis grape hypertension polyphenol A MUSCADINE GRAPE EXTRACT PREVENTS HYPERTENSION-INDUCED CARDIAC AND VASCULAR DAMAGE IN ASSOCIATION WITH ANTI-FIBROTIC AND ANTIOXIDANT MECHANISMS Dissertation Tallant, Elisabeth A Jordan, James E Criswell, Tracy L Varagic, Jasmina Physiology and Pharmacology 2020-05-23 open.access