DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort
Electronic Theses and Dissertations
Item Files
Item Details
- abstract
- Background: P2Y12 receptor is the target for thienopyridine mediated platelet inhibition. Epigenetic factors, including DNA methylation could influence gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA methylation at cis acting CpG sites and P2RY12 gene expression.
- subject
- DNA Methylation
- Gene Expression
- P2RY12
- contributor
- Herrington, David M (committee chair)
- Howard, Timothy D (committee member)
- Liu, Yongmei (committee member)
- Hsu, Fang-Chi (committee member)
- date
- 2015-08-25T08:35:39Z (accessioned)
- 2016-02-24T09:30:09Z (available)
- 2015 (issued)
- degree
- Clinical and Population Translational Sciences (discipline)
- embargo
- 2016-02-24 (terms)
- identifier
- http://hdl.handle.net/10339/57275 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort
- type
- Thesis