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DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort

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title
DNA Methylation and Gene Expression of P2RY12 in a Multi-Ethnic Cohort
author
Cammarata, Michael Wesley
abstract
Background: P2Y12 receptor is the target for thienopyridine mediated platelet inhibition. Epigenetic factors, including DNA methylation could influence gene expression and subsequent in vitro and clinical response to thienopyridine therapy. Our aim was to determine the relationships between DNA methylation at cis acting CpG sites and P2RY12 gene expression.
subject
DNA Methylation
Gene Expression
P2RY12
contributor
Herrington, David M (committee chair)
Howard, Timothy D (committee member)
Liu, Yongmei (committee member)
Hsu, Fang-Chi (committee member)
date
2015-08-25T08:35:39Z (accessioned)
2016-02-24T09:30:09Z (available)
2015 (issued)
degree
Clinical and Population Translational Sciences (discipline)
embargo
2016-02-24 (terms)
identifier
http://hdl.handle.net/10339/57275 (uri)
language
en (iso)
publisher
Wake Forest University
type
Thesis

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