Fibroblast Growth Factor-23 and Cardiac Magnetic Resonance Indices of Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis
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- abstract
- In this thesis, we will evaluate the association of Fibroblast Growth Factor-23 (FGF-23) with myocardial fibrosis using cardiovascular magnetic resonance (CMR) imaging techniques. Higher levels of Fibroblast Growth Factor-23 (FGF-23) have been linked to increased risk of all-cause mortality, cardiovascular mortality, left ventricular hypertrophy and heart failure. Histologic studies on rats suggest an association between higher levels of FGF-23 with myocardial fibrosis. However, it is unknown whether such relationship exists in humans.
- subject
- CKD
- CMR
- FGF-23
- heart failure
- myocardial fibrosis
- contributor
- Herrington, David M (committee chair)
- Jordan, Jennifer Hawthorne (committee member)
- Snively, Beverly M (committee member)
- date
- 2016-05-21T08:35:54Z (accessioned)
- 2017-05-20T08:30:08Z (available)
- 2016 (issued)
- degree
- Clinical and Population Translational Sciences (discipline)
- embargo
- 2017-05-20 (terms)
- identifier
- http://hdl.handle.net/10339/59329 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- title
- Fibroblast Growth Factor-23 and Cardiac Magnetic Resonance Indices of Myocardial Fibrosis in the Multi-Ethnic Study of Atherosclerosis
- type
- Thesis