Home WakeSpace Scholarship › Electronic Theses and Dissertations

FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE

Electronic Theses and Dissertations

Item Files

Item Details

title
FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE
author
Michalson, Kristofer
abstract
Physiologic estrogen loss (menopause) and ionizing radiation exposure are gaining attention as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are currently unclear.
subject
Diastolic Dysfunction
Fibrosis
Heart Failure
Menopause
Monocytes/Macrophages
Radiation
contributor
Register, Thomas C (committee chair)
Cline, J. Mark (committee member)
Brown, Doris R (committee member)
Willey, Jeffrey S (committee member)
Howard, Timothy D (committee member)
date
2019-01-11T09:35:18Z (accessioned)
2021-01-10T09:30:10Z (available)
2018 (issued)
degree
Comparative Medicine (discipline)
embargo
2021-01-10 (terms)
identifier
http://hdl.handle.net/10339/93055 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

Usage Statistics