FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE
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Item Details
- title
- FUNCTIONAL, STRUCTURAL, CELLULAR, AND MOLECULAR CARDIAC RESPONSES IN NONHUMAN PRIMATE MODELS OF MENOPAUSE AND RADIATION EXPOSURE
- author
- Michalson, Kristofer
- abstract
- Physiologic estrogen loss (menopause) and ionizing radiation exposure are gaining attention as drivers of cardiac remodeling leading to heart failure, particularly heart failure with preserved ejection fraction (HFpEF). Myocardial fibrosis appears to be a shared pathologic feature of both conditions, but the underlying mechanism(s) and end stage results on cardiac function are currently unclear.
- subject
- Diastolic Dysfunction
- Fibrosis
- Heart Failure
- Menopause
- Monocytes/Macrophages
- Radiation
- contributor
- Register, Thomas C (committee chair)
- Cline, J. Mark (committee member)
- Brown, Doris R (committee member)
- Willey, Jeffrey S (committee member)
- Howard, Timothy D (committee member)
- date
- 2019-01-11T09:35:18Z (accessioned)
- 2021-01-10T09:30:10Z (available)
- 2018 (issued)
- degree
- Comparative Medicine (discipline)
- embargo
- 2021-01-10 (terms)
- identifier
- http://hdl.handle.net/10339/93055 (uri)
- language
- en (iso)
- publisher
- Wake Forest University
- type
- Dissertation