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Development of a Multifunctionalized Vascular Scaffolding System to Induce In Situ Endothelial Cell Capture, Smooth Muscle Cell Migration, and Prevention of Inflammatory Cell Infiltration

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title
Development of a Multifunctionalized Vascular Scaffolding System to Induce In Situ Endothelial Cell Capture, Smooth Muscle Cell Migration, and Prevention of Inflammatory Cell Infiltration
author
West-Livingston, Lauren Nicole
abstract
Cardiovascular disease (CVD) is the leading cause of death globally, and is responsible for innumerable complications related to the peripheral vascular system. Peripheral vascular disease and vascular trauma are major contributors toward the need of feasible, effective surgical interventions for vascular repair. While autologous vessels are the gold standard for treatment, synthetic alternatives are necessary for some populations of patients. These synthetic vascular conduits are severely limited and suffer from intimal hyperplasia and loss of patency, requiring intervention relatively soon after the initial surgery.
subject
Anti-Inflammatory Drug Loading
Endothelial Cell Capture
Preclinical Rat Model
Regenerative Medicine
Smooth Muscle Migration
Tissue Engineered Vascular Grafts
contributor
Lee, Sang Jin (committee chair)
Gwathmey-Williams, TanYa M (committee member)
Almeida-Porada, Graça (committee member)
Geary, Randolph L (committee member)
Velazquez-Ramirez, Gabriela (committee member)
date
2020-05-29T08:36:01Z (accessioned)
2020-05-29T08:36:01Z (available)
2020 (issued)
degree
Molecular Medicine and Translational Science (discipline)
identifier
http://hdl.handle.net/10339/96825 (uri)
language
en (iso)
publisher
Wake Forest University
type
Dissertation

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